Diploid embryo complementation of embryonic stem cells efficiently generates a homozygous Gjb2 mutant deaf mouse model
RNA-seq (gene expression) · mouse · 131 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 131 samples: 6 conditions, mostly with about 9 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271800_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1133646 and SRA study SRP518729. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 127 samples.
How we read this: 6 replicated groups read from 131 sample titles; they account for 127 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8385531 35G-deep1 35G-deep
- GSM8385532 35G-deep2 35G-deep
- GSM8385533 35G-deep3 35G-deep
- GSM8385534 35G-deep4 35G-deep
- GSM8385535 35G-deep5 35G-deep
- GSM8385536 35G-deep6 35G-deep
- GSM8385537 GFP1 GFP
- GSM8385538 GFP2 GFP
- GSM8385539 GFP3 GFP
- GSM8385540 GFP4 GFP
- GSM8385541 GFP5 GFP
- GSM8385542 GFP6 GFP
- GSM8385543 GFP7 GFP
- GSM8385544 GFP8 GFP
- GSM8385545 GFP9 GFP
- GSM8385546 GFP10 GFP
- GSM8385547 GFP11 GFP
- GSM8385548 GFP12 GFP
- GSM8385549 GFP13 GFP
- GSM8385550 GFP14 GFP
- GSM8385551 GFP15 GFP
- GSM8385552 GFP16 GFP
- GSM8385553 GFP17 GFP
- GSM8385554 GFP18 GFP
- GSM8385555 GFP19 GFP
- GSM8385556 GFP20 GFP
- GSM8385557 GFP21 GFP
- GSM8385558 GFP22 GFP
- GSM8385559 GFP23 GFP
- GSM8385560 GFP24 GFP
- GSM8385561 GFP25 GFP
- GSM8385562 GFP26 GFP
- GSM8385563 GFP27 GFP
- GSM8385564 GFP28 GFP
- GSM8385565 GFP29 GFP
- GSM8385566 GFP30 GFP
- GSM8385567 GFP31 GFP
- GSM8385568 GFP32 GFP
- GSM8385569 GFP33 GFP
- GSM8385570 GFP34 GFP
+ 91 more — browse all 131 samples with per-sample file links →
- GSE287243 KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [CUT&TAG] 20 samples shares homozygous, embryonic, embryo
- GSE287244 KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan [RNA-seq] 16 samples shares homozygous, embryonic, embryo
- GSE310034 African Pygmy Mouse iPSCs as a Model for In Vitro Embryogenesis, Interspecies Chimerism, and Blastocyst Complementation 1 samples shares complementation, embryo
- GSE308613 Cell-specific delivery of GJB2 restores auditory function in mouse models of DFNB1 deafness and mediates appropriate expression in NHP cochlea 10 samples shares gjb2
- GSE229815 Transcriptional profiling of 12 month striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Msh2 heterozygous or homozygous conditional knockout mice [Msh2_12mon] 138 samples shares homozygous
- GSE288739 Transcriptional profiling of striatum and cortex from a mouse model of Huntington's disease (Q140) crossed with Pms1 heterozygous and homozygous mice 96 samples shares homozygous
- GSE271022 Transcriptional profiling of cerebral cortex and striatum from a mouse model of Huntington's disease (Q140) crossed with Msh6 heterozygous and homozygous mice 96 samples shares homozygous
- GSE229826 Transcriptional profiling of cerebral cortex from a mouse model of Huntington's disease (Q140) crossed with Msh3 heterozygous and homozygous mice [Msh3_cortex] 48 samples shares homozygous
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.