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Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma

GSE273527 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2024/11/25 Platform GPL24676
Summary
Uveal melanoma (UM) is the most common intraocular tumor in adults, and its pathogenesis is only partly understood. UM can develop de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbour UM-initiating mutations, most commonly in GNAQ or GNA11. However, there is a complete lack of commercially available NCM cell lines and no detailed protocol for developing oncogene-mutated CM line (MutCM) to study UM development. The purpose of this study was to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM.
Published in
Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma
Chen Y, Jin E, Abdouh M et al. · BMC biology 2025 · PMID 39838458 · doi:10.1186/s12915-025-02118-w
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Also filed as BioProject PRJNA1142053 and SRA study SRP523189. Searching any of these in the dataset finder brings you back here.

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