Aldehydes alter TGF-β signaling and induce obesity and cancer
RNA-seq (gene expression) · human · 27 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 27 samples: 27 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Aldehydes alter TGF-β signaling and induce obesity and cancerCell reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273561_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1142410 and SRA study SRP523313. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 27 sample titles: 27 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8432342 Aldh2-/-, snRNAseq
- GSM8432343 Aldh2-/-Sptbn1+/-, snRNAseq
- GSM8432344 WT, snRNAseq
- GSM8432345 Sptbn1+/-, snRNAseq
- GSM8432346 siCtrl, replicate 1, RNAseq
- GSM8432347 siCtrl, replicate 2, RNAseq
- GSM8432348 siCtrl, replicate 3, RNAseq
- GSM8432349 25nM siSptbn1, replicate 1, RNAseq
- GSM8432350 25nM siSptbn1, replicate 2, RNAseq
- GSM8432351 25nM siSptbn1, replicate 3, RNAseq
- GSM8432352 50nM siSptbn1, replicate 1, RNAseq
- GSM8432353 50nM siSptbn1, replicate 2, RNAseq
- GSM8432354 50nM siSptbn1, replicate 3, RNAseq
- GSM8443184 wild type, replicate 1, RNAseq
- GSM8443185 wild type, replicate 2, RNAseq
- GSM8443186 wild type, replicate 3, RNAseq
- GSM8443187 wild type, replicate 4, RNAseq
- GSM8443188 wild type, replicate 5, RNAseq
- GSM8443189 Aldh2-/-, replicate 1, RNAseq
- GSM8443190 Aldh2-/-, replicate 2, RNAseq
- GSM8443191 Aldh2-/-, replicate 3, RNAseq
- GSM8443192 Aldh2-/-, replicate 4, RNAseq
- GSM8443193 Aldh2-/-Sptbn1+/-, replicate 1, RNAseq
- GSM8443194 Aldh2-/-Sptbn1+/-, replicate 2, RNAseq
- GSM8443195 Aldh2-/-Sptbn1+/-, replicate 3, RNAseq
- GSM8443196 Aldh2-/-Sptbn1+/-, replicate 4, RNAseq
- GSM8443197 Aldh2-/-Sptbn1+/-, replicate 5, RNAseq
- GSE242839 PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity 29 samples shares obesity, induce
- GSE315101 Soluble DLK1 secreted by telomere-shortening-induced senescent microglia impairs oligodendrocyte functions and alters neuronal activity [DLK1_snRNA-seq] 27 samples shares induce, alter
- GSE253935 Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption 32 samples shares tgf
- GSE241047 PRDM16 deficiency triggered by TGF-β1 signaling promotes aberrant mitochondrial homeostasis and kidney fibrosis 11 samples shares tgf
- GSE270713 Psychological stress increases susceptibility to Staphylococcus aureus infection by the action of TGFβ to suppress immune acting fibroblasts [RNA-Seq] 36 samples shares tgf
- GSE317309 Combination of a CCL21-gene modified dendritic cell vaccine and pembrolizumab induces immune responses in non-small cell lung cancer 64 samples shares induce
- GSE266364 Immunogenic cell death inducer cEmsy boosted cancer immunotherapy in lung adenocarcinoma 33 samples shares induce
- GSE310025 Intrinsic RB activation induces tumoral and stromal anti-tumor responses that limit triple-negative breast cancer [RNA-Seq] 28 samples shares induce
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.