Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 5 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulationGenes to cells : devoted to molecular & cellular mechanisms · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273579_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1142455 and SRA study SRP523363. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 8 samples read as cases, 4 as controls.
How we read this: 5 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8432614 Normal diet fed mouse, Non exercise, mouse1 Normal diet fed mouse, …
- GSM8432615 Normal diet fed mouse, Non exercise, mouse2 Normal diet fed mouse, …
- GSM8432616 Normal diet fed mouse, Non exercise, mouse3 Normal diet fed mouse, …
- GSM8432617 Normal diet fed mouse, Non exercise, mouse4 Normal diet fed mouse, …
- GSM8432618 High fat diet fed mouse, Non exercise, non-tumor tissue, mouse1 High fat diet fed mouse…
- GSM8432619 High fat diet fed mouse, Non exercise, non-tumor tissue, mouse2 High fat diet fed mouse…
- GSM8432620 High fat diet fed mouse, Non exercise, non-tumor tissue, mouse3 High fat diet fed mouse…
- GSM8432621 High fat diet fed mouse, Non exercise, non-tumor tissue, mouse4 High fat diet fed mouse…
- GSM8432622 High fat diet fed mouse, Non exercise, tumor tissue, mouse1 High fat diet fed mouse…
- GSM8432623 High fat diet fed mouse, Non exercise, tumor tissue, mouse2 High fat diet fed mouse…
- GSM8432624 High fat diet fed mouse, Non exercise, tumor tissue, mouse3 High fat diet fed mouse…
- GSM8432625 High fat diet fed mouse, Non exercise, tumor tissue, mouse4 High fat diet fed mouse…
- GSM8432626 High fat diet fed mouse, Exercise, non-tumor tissue, mouse1 High fat diet fed mouse…
- GSM8432627 High fat diet fed mouse, Exercise, non-tumor tissue, mouse2 High fat diet fed mouse…
- GSM8432628 High fat diet fed mouse, Exercise, non-tumor tissue, mouse3 High fat diet fed mouse…
- GSM8432629 High fat diet fed mouse, Exercise, non-tumor tissue, mouse4 High fat diet fed mouse…
- GSM8432630 High fat diet fed mouse, Exercise, tumor tissue, mouse1 High fat diet fed mouse…
- GSM8432631 High fat diet fed mouse, Exercise, tumor tissue, mouse2 High fat diet fed mouse…
- GSM8432632 High fat diet fed mouse, Exercise, tumor tissue, mouse3 High fat diet fed mouse…
- GSM8432633 High fat diet fed mouse, Exercise, tumor tissue, mouse4 High fat diet fed mouse…
- GSE304653 Exercise suppresses breast cancer and reprograms the immune tumor microenvironment, cancer cell intrinsic features, and their interaction 23 samples shares suppresses, exercise
- GSE324100 Exercise Training Prior To and During Cancer in Mice Preserves Muscle Mass, Reduces Tumor Weight, and Suppresses Molecular Mediators of Cachexia 22 samples shares suppresses, exercise
- GSE278216 SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain 115 samples shares upregulation, suppresses
- GSE62628 Voluntary exercise suppresses tumor growth through exercise-directed recruitment and intratumoral infiltration of NK cells 10 samples shares suppresses, exercise
- GSE296085 E2F1 induces a G0-G1 re-entry transcriptional program without changing chromatin accessibility [RNA-seq] 22 samples shares e2f1
- GSE313209 Hv1 upregulation worsens spinal, spleen, and lung molecular pathology and impairs locomotion after spinal cord injury in aged male mice 123 samples shares upregulation
- GSE254996 ACSS2 upregulation enhances neuronal resilience to aging and neurodegeneration [RNA-seq] 98 samples shares upregulation
- GSE313654 Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer [RNAseq_MycRux] 58 samples shares suppresses
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.