Parental Alcohol Exposures Promote Increased Susceptibility to Hepatocellular Carcinoma in Adult Male Offspring
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 20 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Parental Alcohol Use Disrupts Offspring Mitochondrial Activity, Promoting Susceptibility to Toxicant-Induced Liver CancerAging and disease · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273675_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1142598 and SRA study SRP523411. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 20 sample titles: 20 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8434965 Control1_Saline
- GSM8434966 Control2_Saline
- GSM8434967 Control3_Saline
- GSM8434968 Control4_Saline
- GSM8434969 Control1_DEN
- GSM8434970 Control2_DEN
- GSM8434971 Control3_DEN
- GSM8434972 Control4_DEN
- GSM8434973 Paternal1_DEN
- GSM8434974 Paternal2_DEN
- GSM8434975 Paternal3_DEN
- GSM8434976 Paternal4_DEN
- GSM8434977 Maternal1_DEN
- GSM8434978 Maternal2_DEN
- GSM8434979 Maternal3_DEN
- GSM8434980 Maternal4_DEN
- GSM8434981 Dual1_DEN
- GSM8434982 Dual2_DEN
- GSM8434983 Dual3_DEN
- GSM8434984 Dual4_DEN
- GSE324852 Preconception exposures of female mice to a panel of metabolic disruptors induce sexually dimorphic metabolic perturbations in their offspring 100 samples shares exposures, offspring
- GSE235264 Dietary tyramine promotes colon cancer risk and development via increased DNA damage and enhanced inflammation [ApcMin/+] 69 samples shares increased, promote
- GSE284730 Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress 39 samples shares susceptibility, promote
- GSE263273 Increased hepatoprotective effects of the novel farnesoid X receptor agonist INT-787 versus obeticholic acid in a mouse model of nonalcoholic steatohepatitis 28 samples shares increased, alcohol
- GSE309614 TDO2 promotes hepatocellular carcinoma by regulating tryptophan-kynurenine pathway 20 samples shares hepatocellular, promote
- GSE301140 Dual Programmed Death Receptor-1 and Vascular Endothelial Growth Factor Receptor-2 Blockade Promotes Vascular Normalization and Enhances Antitumor Immune Responses in Hepatocellular Carcinoma 18 samples shares hepatocellular, promote
- GSE230838 Loss of cisPTase function in the liver promotes a highly penetrant form of fatty liver disease that rapidly transitions to hepatocellular carcinoma [RNA-seq] 17 samples shares hepatocellular, promote
- GSE267720 Transgenerational inheritance of diabetes susceptibility in male offspring with maternal hyperandrogenism 11 samples shares susceptibility, offspring
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.