GEO series
Hepatic transcriptome of pulmonary TB infection.
GSE273691
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/09/17
GPL13112
Summary
Pulmonary tuberculosis (TB) generates chronic systemic inflammation and metabolic dysregulation. The liver is the master regulator of metabolism and to determine the impact of pulmonary TB on this organ we undertook unbiased mRNA analyses of the liver in mice with TB. Pulmonary TB led to upregulation of genes in the liver related to interferon signalling and glycolysis, and downregulation of genes encoding gluconeogenesis rate-limiting enzyme
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Paper (PMID 39331683) ↗
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