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Gene expression responses to oxygen challenge in a panel of human brain organoids

GSE273907 Homo sapiens Expression profiling by high throughput sequencing 7 samples Submitted 2024/09/05 Platform GPL24676
Summary
The human brain is highly sensitive to oxygen availability, and hypoxia is a common risk factor for neurological and cognitive traits throughout life. Hypoxia exerts distinct effects on different brain cell types, many of which involve changes in gene expression. We used brain organoids derived from genotyped human iPSC lines to characterize gene expression at single-cell resolutions under normoxic conditions and both hypoxic and hyperoxic challenges.
Published in
Oxygen-induced stress reveals context-specific gene regulatory effects in human brain organoids
Umans BD, Gilad Y · bioRxiv : the preprint server for biology 2024 · PMID 39282424 · doi:10.1101/2024.09.03.611030
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Also filed as BioProject PRJNA1143585 and SRA study SRP523987. Searching any of these in the dataset finder brings you back here.

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