GEO series
Gene-specific reactivation of X-linked genes upon Xist loss is linked to the chromatin states in extraembryonic endoderm and epiblast stem cells
GSE273917
Mus musculus
Expression profiling by high throughput sequencing
13 samples
2025/01/28
GPL17021GPL24247
Summary
In this study, we have explored the role of Xist and DNA methylation in the maintenance of X-linked gene silencing in extraembryonic endoderm and epiblast stem cells. We show that only a subset of genes are dependent on Xist and DNA methylation to maintain their inactive state. Moreover, we show that the reactivation potential of X-linked genes upon loss of Xist is connected to the epigenomic states.
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Paper (PMID 39486405) ↗
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