Platelet activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumors
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 3 × Cont vs 3 × PAFGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Platelet-activating factor (PAF) promotes immunosuppressive neutrophil differentiation within tumorsProceedings of the National Academy of Sciences of the United States of America · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE273979_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1144399 and SRA study SRP524425. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8441005 D1_A
- GSM8441006 D1_B
- GSM8441007 D1_C
- GSM8441008 D2_A
- GSM8441009 D2_B
- GSM8441010 D2_C
- GSM8441011 Cont1 Cont
- GSM8441012 Cont2 Cont
- GSM8441013 Cont3 Cont
- GSM8441014 PAF1 PAF
- GSM8441015 PAF2 PAF
- GSM8441016 PAF3 PAF
- GSE233650 The exposure of prenatal enriched environment promotes fetal neuronal development via activating AHR-Src pathway 16 samples shares activating, promotes
- GSE283887 Piezo1 promotes the progression of necrotizing enterocolitis via activating Ca2(+)/CaMKII-dependent pathway 12 samples shares activating, promotes
- GSE298273 Tumor-derived RAC1A159V mutation promotes an immunosuppressive tumor microenvironment that represses response to immune checkpoint inhibitor [RNA-Seq] 12 samples shares immunosuppressive, promotes
- GSE309959 Neutrophil-induced lipoxygenase subtype promotes resolution of acute lung injury in mice 10 samples shares neutrophil, promotes
- GSE248653 Nicotinamide mononucleotide promotes female germline stem cell proliferation by activating the H4K16ac-Hmgb1-Fyn-PLD signaling pathway through epigenetic remodeling 20 samples shares activating, promotes
- GSE282802 KMT2D controls cerebellar granule cell differentiation by temporally activating neuronal transcriptional factor genes [CUT&RUN] 10 samples shares activating, factor
- GSE260700 Glucose-driven histone lactylation promotes the immunosuppressive activity of monocyte-derived macrophages in glioblastoma 6 samples shares immunosuppressive, promotes
- GSE279924 Propafenone facilitates mitochondrial-associated ferroptosis and synergizes with immunotherapy in melanoma 20 samples shares paf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.