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Study of gene expression in mouse primary hepatocytes cultured in hydrogels with different stiffnesses in wild-type and YAP/TAZ knockout.

GSE274047 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/05/15 Platform GPL24247
Summary
Liver stiffness is extensively utilized as a crucial indicator in the diagnosis and monitoring of MASLD, the contribution of increased stiffness on impaired liver functions and its molecular mechanisms remains poorly understood. Wild-type or Yap/Taz knock-out hepatocytes were cultured on soft (1 kPa) and stiff (20 kPa) hydrogels to embody healthy and fibrotic livers and subjected to metabolomic and transcriptomic analyses.
Published in
Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction-Associated Steatotic Liver Disease
Lee NY, Choi MG, Ryu HJ et al. · Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 · PMID 41747066 · doi:10.1002/advs.202500379
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Also filed as BioProject PRJNA1144779 and SRA study SRP524460. Searching any of these in the dataset finder brings you back here.

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