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Reduction of SIRPα connects podocyte metabolism dysfunction to inflammatory activation via promoting PKM2 nuclear translocation in diabetes nephropathy II

GSE274089 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/18 Platform GPL17021
Summary
A central cause of diabetic nephropathy (DN) is podocyte injury. There are many factors causing podocyte injury in DN, such as hyperglycemia, oxidative stress and inflammation. In this study, a signal regulator protein α (SIRPα) was found to play a critical role in regulating podocyte metabolism, oxidative stress and inflammatory.
Published in
Podocyte SIRPα reduction in diabetic nephropathy aggravates podocyte injury by promoting pyruvate kinase M2 nuclear translocation
Chen Y, Zhang M, Jia R et al. · Redox biology 2024 · PMID 39586122 · doi:10.1016/j.redox.2024.103439
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Also filed as BioProject PRJNA1144922 and SRA study SRP524609. Searching any of these in the dataset finder brings you back here.

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