Recurrent FGFR-alterations are frequent oncogenic drivers and therapeutic targets in pediatric low-grade gliomas
RNA-seq (gene expression) · human · 68 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 68 samples: 8 conditions, mostly with about 8 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A diverse landscape of FGFR alterations and co-mutations suggests potential therapeutic strategies in pediatric low-grade gliomasNature communications · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274098_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1144947 and SRA study SRP524257. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 64 samples.
How we read this: 8 replicated groups read from 68 sample titles; they account for 64 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8441159 Vector control r1 Vector control
- GSM8441160 Vector control r2 Vector control
- GSM8441161 Vector control r3 Vector control
- GSM8441162 PTPN11 E69K alone r1 PTPN11 E69K alone
- GSM8441163 PTPN11 E69K alone r2 PTPN11 E69K alone
- GSM8441164 PTPN11 E69K alone r3 PTPN11 E69K alone
- GSM8441165 FGFR1 N546K r1 FGFR1 N546K
- GSM8441166 FGFR1 N546K r2 FGFR1 N546K
- GSM8441167 FGFR1 N546K r3 FGFR1 N546K
- GSM8441168 FGFR1 N546K + PTPN11 E69K r1 FGFR1 N546K + PTPN11 E6…
- GSM8441169 FGFR1 N546K + PTPN11 E69K r2 FGFR1 N546K + PTPN11 E6…
- GSM8441170 FGFR1 N546K + PTPN11 E69K r3 FGFR1 N546K + PTPN11 E6…
- GSM8441171 FGFR1:TACC1 r1 TACC1
- GSM8441172 FGFR1:TACC1 r2 TACC1
- GSM8441173 FGFR1:TACC1 r3 TACC1
- GSM8441174 FGFR1-ITD r1 FGFR1-ITD
- GSM8441175 FGFR1-ITD r2 FGFR1-ITD
- GSM8441176 FGFR1-ITD r3 FGFR1-ITD
- GSM8441177 BRAF V600E r1 BRAF V600E
- GSM8441178 BRAF V600E r2 BRAF V600E
- GSM8441179 BRAF V600E r3 BRAF V600E
- GSM8441180 KIAA1549:BRAF r1 BRAF
- GSM8441181 KIAA1549:BRAF r2 BRAF
- GSM8441182 KIAA1549:BRAF r3 BRAF
- GSM8441183 FGFR1_N546K_LACZ
- GSM8441184 FGFR1_PTPN11
- GSM8441185 FGFR1_ITD
- GSM8441186 FGFR1_TACC1
- GSM8729382 Vector control r1 Vector control
- GSM8729383 Vector control r2 Vector control
- GSM8729384 Vector control r3 Vector control
- GSM8729385 Vector control r4 Vector control
- GSM8729386 Vector control r5 Vector control
- GSM8729387 PTPN11 E69K alone r1 PTPN11 E69K alone
- GSM8729388 PTPN11 E69K alone r2 PTPN11 E69K alone
- GSM8729389 PTPN11 E69K alone r3 PTPN11 E69K alone
- GSM8729390 PTPN11 E69K alone r4 PTPN11 E69K alone
- GSM8729391 PTPN11 E69K alone r5 PTPN11 E69K alone
- GSM8729392 FGFR1 N546K r1 FGFR1 N546K
- GSM8729393 FGFR1 N546K r2 FGFR1 N546K
+ 28 more — browse all 68 samples with per-sample file links →
- GSE294901 Measles oncolytic virus as an immunotherapy for recurrent/refractory pediatric medulloblastoma and atypical teratoid rhabdoid tumor: results from PNOC005 84 samples shares recurrent, pediatric
- GSE97117 Integrated target discovery screens identify IL11 as novel therapeutic target for fibrosis 212 samples shares therapeutic
- GSE285764 Single Alkyl Phosphonate Modification of the siRNA Backbone in the Seed Region Enhances Specificity and Therapeutic Profile 110 samples shares therapeutic
- GSE294247 The PRMT5-splicing axis is a critical oncogenic vulnerability that regulates detained intron splicing 110 samples shares oncogenic
- GSE283531 MOZ and HBO1 Histone Acetyltransferase Complexes Are Molecular Dependencies and Therapeutic Targets in NUP98-Rearranged Acute Myeloid Leukemia [RNA-Seq] 54 samples shares therapeutic
- GSE279100 Differential KEAP1/NRF2-mediated signaling widens the therapeutic window of redox-targeting drugs in SCLC therapy [seq] 50 samples shares therapeutic
- GSE315010 Abrogation of Oncogenic RAS Signaling by a RAS(ON) Inhibitor Doublet Primes Immune-refractory KRASG12C-mutant NSCLC for Immune Checkpoint Blockade 44 samples shares oncogenic
- GSE307527 ARID1A and ARID1B preserve B cell identity, prevent myeloid transformation and reveal therapeutic vulnerabilities 30 samples shares therapeutic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.