GEO series
Mature optic nerve regeneration requires ligand-independent expression of the LIF receptor
GSE274285
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2025/09/01
GPL24247
Summary
To investigate the molecular consequences of LIFR expression, RGCs were FACS-isolated from vglut2-tdTomato mice two weeks following intraocular AAV2-LIFR, AAV2-Ctrl or AAV2-shLIFR, AAV2-shScramble and then analyzed by bulk RNA-seq. AAV2-LIFR and AAV2-shLIFR had a pronounced transcriptional effect on adult RGCs compared to the control group.
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