Chromogranin A (CgA) Deficiency Attenuates Tauopathy by Altering Epinephrine–Alpha-Adrenergic Receptor Signaling
RNA-seq (gene expression) · mouse · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 6 × hTau, vs 6 × CgA-KO/hTau, vs 5 × Wild-type,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Chromogranin A deficiency attenuates tauopathy by altering epinephrine-alpha-adrenergic receptor signaling in PS19 miceNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274459_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1146456 and SRA study SRP525448. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 17 samples.
How we read this: 3 replicated groups read from 17 sample titles; they account for 17 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8449581 Wild-type, rep1 Wild-type,
- GSM8449582 Wild-type, rep2 Wild-type,
- GSM8449583 Wild-type, rep3 Wild-type,
- GSM8449584 Wild-type, rep4 Wild-type,
- GSM8449585 Wild-type, rep5 Wild-type,
- GSM8449586 hTau, rep1 hTau,
- GSM8449587 hTau, rep2 hTau,
- GSM8449588 hTau, rep3 hTau,
- GSM8449589 hTau, rep4 hTau,
- GSM8449590 hTau, rep5 hTau,
- GSM8449591 hTau, rep6 hTau,
- GSM8449592 CgA-KO/hTau, rep1 CgA-KO/hTau,
- GSM8449593 CgA-KO/hTau, rep2 CgA-KO/hTau,
- GSM8449594 CgA-KO/hTau, rep3 CgA-KO/hTau,
- GSM8449595 CgA-KO/hTau, rep4 CgA-KO/hTau,
- GSM8449596 CgA-KO/hTau, rep5 CgA-KO/hTau,
- GSM8449597 CgA-KO/hTau, rep6 CgA-KO/hTau,
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- GSE264041 TET2 Deficiency Increases the Competitive Advantage of Hematopoietic Stem Cells through Upregulation of Thrombopoietin Receptor Signaling 28 samples shares deficiency, receptor
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.