RNA sequencing of psoriasis and healthy keratinocytes
RNA-seq (gene expression) · human · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 × Healthy, vs 8 × Psoriasis,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- RNA Sequencing Reveals the Long Non-Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non-Coding RNA Regulating Epidermal DifferentiationExperimental dermatology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274560_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1147211 and SRA study SRP526534. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 2 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8452907 Healthy, 1 Healthy,
- GSM8452908 Healthy, 2 Healthy,
- GSM8452909 Healthy, 3 Healthy,
- GSM8452910 Healthy, 4 Healthy,
- GSM8452911 Healthy, 5 Healthy,
- GSM8452912 Healthy, 6 Healthy,
- GSM8452913 Healthy, 7 Healthy,
- GSM8452914 Healthy, 8 Healthy,
- GSM8452915 Psoriasis, 1 Psoriasis,
- GSM8452916 Psoriasis, 2 Psoriasis,
- GSM8452917 Psoriasis, 3 Psoriasis,
- GSM8452918 Psoriasis, 4 Psoriasis,
- GSM8452919 Psoriasis, 5 Psoriasis,
- GSM8452920 Psoriasis, 6 Psoriasis,
- GSM8452921 Psoriasis, 7 Psoriasis,
- GSM8452922 Psoriasis, 8 Psoriasis,
- GSE282206 NLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis 24 samples shares keratinocytes, psoriasis
- GSE295540 RNA-seq result of human skin derived from patients with psoriasis and healthy controls. 13 samples shares psoriasis, healthy
- GSE254707 Single-cell transcriptomic analysis identifies infiltrating plasmacytoid dendritic cells in psoriasis epidermis 4988 samples shares psoriasis
- GSE279480 Longitudinally stable T cell and innate immune activity distinguish healthy adult immunotypes I 1021 samples shares healthy
- GSE279552 Longitudinally stable T cell and innate immune activity distinguish healthy adult immunotypes [II] 864 samples shares healthy
- GSE288904 Transcriptome Sequencing Data of Peripheral Blood Neutrophils in Multiple Sclerosis Patients and Healthy Volunteers 37 samples shares healthy
- GSE287022 Cutaneous adipose tissue has a strong inflammatory signature in psoriasis patients, and it is partly IL-17 dependent. 241 samples shares psoriasis
- GSE285522 Bulk RNA sequencing of skin biopsies from psoriasis patients treated with Dead Sea climatotherapy 30 samples shares psoriasis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.