Enhancing Non-Small Cell Lung Cancer Treatment Utilizing Natural Killer Cell-Derived Extracellular Vesicles (NKEVS) As A Novel Adoptive Cellular Therapeutic [PBMC]
Single-cell RNA-seq · human · 57 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Topic
- Lung cancerThis series is part of our curated briefing on it.
- Samples
- 57 samples: 57 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancerFrontiers in immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274588_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1147249 and SRA study SRP526010. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 57 sample titles: 57 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8453213 PBMC, pre-tumor resection, patient 2, gene expression library
- GSM8453221 PBMC, post-tumor resection, patient 2, gene expression library
- GSM8453223 PBMC, pre-tumor resection, patient 4, gene expression library
- GSM8453224 PBMC, post-tumor resection, patient 4, gene expression library
- GSM8453225 PBMC, pre-tumor resection, patient 5, gene expression library
- GSM8453226 PBMC, post-tumor resection, patient 5, gene expression library
- GSM8453227 PBMC, pre-tumor resection, patient 6, gene expression library
- GSM8453228 PBMC, post-tumor resection, patient 6, gene expression library
- GSM8453229 PBMC, pre-tumor resection, patient 7, gene expression library
- GSM8453230 PBMC, post-tumor resection, patient 7, gene expression library
- GSM8453231 PBMC, pre-tumor resection, patient 8, gene expression library
- GSM8453232 PBMC, post-tumor resection, patient 8, gene expression library
- GSM8453233 PBMC, pre-tumor resection, patient 9, gene expression library
- GSM8453234 PBMC, post-tumor resection, patient 9, gene expression library
- GSM8453235 PBMC, pre-tumor resection, patient 10, gene expression library
- GSM8453236 PBMC, pre-tumor resection, patient 12, gene expression library
- GSM8453237 PBMC, post-tumor resection, patient 12, gene expression library
- GSM8453238 PBMC, pre-tumor resection, patient 14, gene expression library
- GSM8453239 PBMC, post-tumor resection, patient 14, gene expression library
- GSM8453240 PBMC, pre-tumor resection, patient 2, VDJ recombination library
- GSM8453241 PBMC, post-tumor resection, patient 2, VDJ recombination library
- GSM8453242 PBMC, pre-tumor resection, patient 4, VDJ recombination library
- GSM8453243 PBMC, post-tumor resection, patient 4, VDJ recombination library
- GSM8453244 PBMC, pre-tumor resection, patient 5, VDJ recombination library
- GSM8453245 PBMC, post-tumor resection, patient 5, VDJ recombination library
- GSM8453246 PBMC, pre-tumor resection, patient 6, VDJ recombination library
- GSM8453247 PBMC, post-tumor resection, patient 6, VDJ recombination library
- GSM8453248 PBMC, pre-tumor resection, patient 7, VDJ recombination library
- GSM8453249 PBMC, post-tumor resection, patient 7, VDJ recombination library
- GSM8453250 PBMC, pre-tumor resection, patient 8, VDJ recombination library
- GSM8453251 PBMC, post-tumor resection, patient 8, VDJ recombination library
- GSM8453252 PBMC, pre-tumor resection, patient 9, VDJ recombination library
- GSM8453253 PBMC, post-tumor resection, patient 9, VDJ recombination library
- GSM8453254 PBMC, pre-tumor resection, patient 10, VDJ recombination library
- GSM8453255 PBMC, pre-tumor resection, patient 12, VDJ recombination library
- GSM8453256 PBMC, post-tumor resection, patient 12, VDJ recombination library
- GSM8453257 PBMC, pre-tumor resection, patient 14, VDJ recombination library
- GSM8453258 PBMC, post-tumor resection, patient 14, VDJ recombination library
- GSM8453259 PBMC, pre-tumor resection, patient 2, cell surface antibody barcode library
- GSM8453260 PBMC, post-tumor resection, patient 2, cell surface antibody barcode library
+ 17 more — browse all 57 samples with per-sample file links →
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- GSE241518 High-throughout sequencing of colorectal cancer and non-small cell lung cancer cells treated actived compound YHM18 4 samples same disease briefing · shares non-small
- GSE10072 Gene expression signature of cigarette smoking and its role in lung adenocarcinoma development and survival 107 samples same disease briefing
- GSE17958 Affymetrix SNP array data for 47 lung squamous cell carcinoma and 40 esophageal squamous cell carcinoma samples. 87 samples same disease briefing
- GSE127465 Single cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species 40 samples same disease briefing
- GSE104244 Bone Marrow Derived Macrophages, NSCLC cell lines, and Kras G12D Lung Tumors Treated with Epigenetic Agents 33 samples same disease briefing
- GSE103550 Lung Cancer Cell-Mediated Skeletal Muscle Mitochondrial Dysfunction is Mitigated by 1a,25-Dihydroxyvitamin D3 24 samples same disease briefing
- GSE27389 Substitutions in the KRas oncogene determine protein behavior: Implications for signaling and clinical outcome. 22 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.