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Antigen-specific B cells from inflamed lung and lung-draining lymph node

GSE274691 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/08 Platform GPL30172Platform GPL19057
Summary
Germinal center (GC) like B cells can be generated in unstructured non-ectopic T and B cell infiltrates in the in inflamed lung. We used single cell RNA sequencing (scRNA-seq) for gene expression and B cell receptor (BCR) to compare antigen-specific B cells from lung to those from the lung-draining lymph node.
Published in
Activation and maturation of antigen-specific B cells in nonectopic lung infiltrates are independent of germinal center reactions in the draining lymph node
Schacht SS, Graffunder J, Durek P et al. · Cellular & molecular immunology 2025 · PMID 40210692 · doi:10.1038/s41423-025-01285-8
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Also filed as BioProject PRJNA1147667 and SRA study SRP526174. Searching any of these in the dataset finder brings you back here.

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