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RNA sequencing of tumor-associated macrophages from control-diet- and high-fat-diet-fed C57BL/6J mice

GSE274824 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/18 Platform GPL21103
Summary
Multiple cancers, including colorectal cancer (CRC), are more frequent and often more aggressive in obese individuals. Here, we show that macrophages accumulate within tumors of obese CRC patients and in obese CRC mice and promote accelerated tumor growth. These changes are initiated by oleic acid accumulation and subsequent tumor cell-derived acid production, and driven by signaling through GPR65, an acid-sensing receptor on CRC-associated macrophages. We demonstrate a similar role for GPR65 in hepatocellular carcinoma (HCC) in obese mice. Tumors in obese patients with CRC or HCC also exhibit increased GPR65 expression, suggesting that the mechanism revealed here likely contributes to tumor growth in a range of obesity-associated cancers and represents a potential therapeutic target.
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Also filed as BioProject PRJNA1148135 and SRA study SRP526469. Searching any of these in the dataset finder brings you back here.

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