Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy [RNA-seq]
RNA-seq (gene expression) · mouse · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 17 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapyScience (New York, N.Y.) · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274864_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1148212 and SRA study SRP526468. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 17 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8459585 Rosa, replicate 1, RNA seq
- GSM8459586 Dnmt3a, replicate 1, RNA seq
- GSM8459587 Dnmt3a, replicate 2, RNA seq
- GSM8459588 Asxl1, replicate 1, RNA seq
- GSM8459589 Dnmt3a, replicate 3, RNA seq
- GSM8459590 Dnmt3a, replicate 4, RNA seq
- GSM8459591 Tet2, replicate 1, RNA seq
- GSM8459592 Tet2, replicate 2, RNA seq
- GSM8459593 Asxl1, replicate 2, RNA seq
- GSM8459594 Rosa, replicate 2, RNA seq
- GSM8459595 Rosa, replicate 3, RNA seq
- GSM8459596 Rosa, replicate 4, RNA seq
- GSM8459597 Rosa, replicate 5, RNA seq
- GSM8459598 Tet2, replicate 3, RNA seq
- GSM8459599 Tet2, replicate 4, RNA seq
- GSM8459600 Asxl1, replicate 3, RNA seq
- GSM8459601 Asxl1, replicate 4, RNA seq
- GSE274865 Epigenetic regulators of clonal hematopoiesis control CD8 T cell stemness during immunotherapy [CUT&Tag] 36 samples shares cd8, hematopoiesis, immunotherapy, epigenetic, regulators, stemness, control
- GSE327604 Epigenetic control of microglial mitochondrial immunity by KAT7 drives Alzheimer’s disease pathogenesis [RNA-Seq] 12 samples shares epigenetic, control, rna-seq
- GSE302682 Sleeping Beauty mutagenesis identifies BACH2 and other regulators promoting CD8+ T cell persistence and effector function under tumor-associated chronic antigen stimulation - RNAseq 66 samples shares cd8, regulators
- GSE306744 Pre-division TCF1 downregulation determines long-term effector and memory CD8 T cell fates [RNA-Seq] 31 samples shares cd8, rna-seq
- GSE215759 Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells [RNA-seq] 15 samples shares cd8, rna-seq
- GSE275974 SATB1 is a key regulator of quiescence in stem-like CD8+ T cells [RNA-seq] 10 samples shares cd8, rna-seq
- GSE304763 A pan-immunotherapy signature to predict intratumoral CD8+ T cell expansions [scTCR_immunotherapies] 91 samples shares cd8, immunotherapy
- GSE255887 HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection 76 samples shares cd8, control
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.