A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [RNAseq_mouse]
RNA-seq (gene expression) · mouse · 19 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 19 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- A mutant ASXL1-BAP1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemiaProceedings of the National Academy of Sciences of the United States of America · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE274878_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1148402 and SRA study SRP526583. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 19 samples.
How we read this: 6 replicated groups read from 19 sample titles; they account for 19 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8459804 Cd11b,young,MT,Rep1 Cd11b,young,MT,
- GSM8459805 Cd11b,young,MT,Rep2 Cd11b,young,MT,
- GSM8459806 Cd11b,young,MT,Rep3 Cd11b,young,MT,
- GSM8459807 Cd11b,young,WT,Rep1 Cd11b,young,WT,
- GSM8459808 Cd11b,young,WT,Rep2 Cd11b,young,WT,
- GSM8459809 Cd11b,young,WT,Rep3 Cd11b,young,WT,
- GSM8459810 Cd11b,young,WT,Rep4 Cd11b,young,WT,
- GSM8459811 Cd11b,old,MT,Rep1 Cd11b,old,MT,
- GSM8459812 Cd11b,old,MT,Rep2 Cd11b,old,MT,
- GSM8459813 Cd11b,old,MT,Rep3 Cd11b,old,MT,
- GSM8459814 Cd11b,old,WT,Rep1 Cd11b,old,WT,
- GSM8459815 Cd11b,old,WT,Rep2 Cd11b,old,WT,
- GSM8459816 Cd11b,old,WT,Rep3 Cd11b,old,WT,
- GSM8459817 LK,MT,Rep1 LK,MT,
- GSM8459818 LK,MT,Rep2 LK,MT,
- GSM8459819 LK,MT,Rep3 LK,MT,
- GSM8459820 LK,WT,Rep1 LK,WT,
- GSM8459821 LK,WT,Rep2 LK,WT,
- GSM8459822 LK,WT,Rep3 LK,WT,
- GSE274875 A mutant ASXL1-EHMT complex contributes to heterochromatin dysfunction in clonal hematopoiesis and chronic monomyelocytic leukemia [Cut & Run] 38 samples shares asxl1-ehmt, heterochromatin, monomyelocytic, hematopoiesis, contributes, dysfunction, leukemia, complex
- GSE276311 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [RNA-seq] 61 samples shares hematopoiesis, leukemia
- GSE312282 In vivo CRISPR screening identifies SAGA complex members as a key regulators of hematopoiesis [RNA] 56 samples shares hematopoiesis, complex
- GSE276312 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [scRNA-seq] 23 samples shares hematopoiesis, leukemia
- GSE266580 Ablation of Id1 Reduces Clonal Hematopoiesis, Genomic Instability and Delays Leukemia in Mice with Tet2 Loss of Function [RNA-seq] 12 samples shares hematopoiesis, leukemia
- GSE294772 Single-Cell Epigenomics Uncovers Heterochromatin Instability and Transcription Factor Dysfunction during Mouse Brain Aging [snATAC-Seq] [10X Multiome] 142 samples shares heterochromatin, dysfunction
- GSE261181 Regulation of heterochromatin formation and tumor suppression in leukemia by IKAROS, HDAC1 and EZH2 [ChIP-seq] 28 samples shares heterochromatin, leukemia
- GSE276308 Two mutations associated with leukemia that change a single tyrosine residue in the STAT5B SH2 domain have opposite effects on the transcriptional programs controlling hematopoiesis [ChIP-seq] 13 samples shares hematopoiesis, leukemia
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.