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TGF-beta mediated hepatic stellate cells activation is dampened in the absence of EPHB2 in vitro.

GSE274898 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/31 Platform GPL24676
Summary
Hepatic stellate cells (HSCs) are the major effector cell-type responsible for the production of collagens in hepatic fibrogenesis. In this study we showed that when EPHB2 is silenced in human primary HSCs, they become refractory to TGFbeta-induced-HSCs-to-myofibroblasts transdifferentiation. More importantly, EphB2-specific deletion in HSCs using the tamoxifen inducible PdgfCre-eRT2 promoer driver is sufficient to mitigate MASH fibrosis in mice.
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Also filed as BioProject PRJNA1148427 and SRA study SRP526581. Searching any of these in the dataset finder brings you back here.

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