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EphB2 deficiency in hepatic stellate cells mitigated MASH fibrosis in mice.

GSE274899 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2026/01/31 Platform GPL24247
Summary
Metabolic dysfunction-associated steatohepatitis (MASH) is emerging as the leading cause for liver transplantation worldwide. MASH is chatacterized by hepatic lipid accumulation, inlammation and fibrosis which is associaed with worst outcome in patients sufferreing from this pathology. Using the murine choline deficient amino acid defined high fat diet (CDAA-HFD) model of MASH we showed that Ephb2-specific deletion in HSCs using the tamoxifen inducible PdgfCre-eRT2 promoer driver is sufficient to mitigate MASH fibrosis in mice.
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Also filed as BioProject PRJNA1148426 and SRA study SRP526579. Searching any of these in the dataset finder brings you back here.

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