← BioTransfer GEO Dataset Finder
GEO series

The role of TIGIT in idiopathic inflammatory myopathies

GSE275016 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/26 Platform GPL23479
Summary
To investigate the role of Tight in idiopathic inflammatory myopathies.We evaluated global transcriptome changes in the quadriceps muscles of Tight-/- and WT mice with EAE. For EAM induction, 6-week-old female BALB/c mice were immunized with 100 μl of 50% complete Freund’s adjuvant (Sigma, USA) containing 1mg myosin (or with an equal volume of PBS in control group) on bilateral sides of the hind foot pads, the tail base and flanks four times at 1-week intervals as previously described.
Published in
TIGIT deficiency promotes autoreactive CD4(+) T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis
Lai Y, Wang S, Ren T et al. · Nature communications 2025 · PMID 40374622 · doi:10.1038/s41467-025-59786-z
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE275016_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1148962 and SRA study SRP526852. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.