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RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond

GSE275035 Mus musculus (mouse) Non-coding RNA profiling 27 samples Submitted 2025/12/02 Platform GPL24973Platform GPL24247
At a glance

Non-coding RNA profiling · mouse · 27 samples

What it is
Non-coding RNA profilingLevels of RNAs that do not code for proteins, such as miRNA or lncRNA.
Organism
Mus musculus (mouse)
Samples
27 samples: 9 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyondScientific reports · 2025
SuperSeries — this record groups several sub-series.
Summary (written by the submitters)
This SuperSeries is composed of the SubSeries listed below.
Published in
RNA modifications, alternative splicing and circular RNA landscape in the mouse brain: inosine and beyond
Larrea E, Tellaetxe-Abete M, Peng Y et al. · Scientific reports 2025 · PMID 41310151 · doi:10.1038/s41598-025-30030-4
This dataset
Open GSE275035 in finder → Find more mouse RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275035_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

Also filed as BioProject PRJNA1148994 and SRA study SRP516751. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 41310151) ↗
Study design
9 conditions, mostly in triplicate
Mouse brain, wild type, mRNA, ×3 Mouse brain, Adar2KO, mRNA, ×3 Mouse brain, Adar1-2KO, mRNA, ×3 Mouse brain, wild type, circRNA, Illumina, ×3 Mouse brain, Adar2KO, circRNA, Illumina, ×3 Mouse brain, Adar1-2KO, circRNA, Illumina, ×3 Mouse brain, wild type, circRNA, ONT, ×3 Mouse brain, Adar2KO, circRNA, ONT, ×3 +1 more

Supports a between-group comparison across 27 samples.

How we read this: 9 replicated groups read from 27 sample titles; they account for 27 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all mouse RNA-seq datasets in GEO →

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