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Genome-wide analysis of H3K27ac and RBPJ distribution in a human chronic B cell leukemia cell line.

GSE275036 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 5 samples Submitted 2025/08/06 Platform GPL24676
Summary
The Notch signaling pathway regulates several processes including development and differentiation and its aberrant regulation leads to several diseases such as leukemia. Here, we investigated the genome-wide distribution of the transcription factor RBPJ and of the active histone mark H3K27ac in a human chronic B cell leukemia cell line called HG3.
Published in
NOTCH1 signaling is dysregulated by loss of the deubiquitinase USP28 with del(11q), uncovering USP28 inhibition as novel therapeutic target in CLL
Ehrmann AS, Quijada-Álamo M, Close V et al. · Leukemia 2025 · PMID 40456839 · doi:10.1038/s41375-025-02632-4
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Also filed as BioProject PRJNA1149000 and SRA study SRP526885. Searching any of these in the dataset finder brings you back here.

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