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Single-Cell Sequencing Unveils Distal and Proximal Features of Induced Pluripotent Stem Cell-Derived Intestinal Organoids and cAMP’s role in enhancing multicellularity intestinal lineage specification.

GSE275068 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/16 Platform GPL30173
Summary
This study aims to advance intestinal organoid models by characterizing mesenchyme-free regional-specific induced pluripotent stem cell (iPSC)-derived human intestinal organoids (HIOs) at single-cell resolution and investigating the impact of cyclic AMP (cAMP) on intestinal differentiation lineage specification.
Published in
Human-induced Pluripotent Stem Cell-derived Gut Organoids Recapitulate Regional Specific Genetic Programs and a Role for cAMP in Lineage Specification
Flores EY, Mithal A, Bawa P et al. · Cellular and molecular gastroenterology and hepatology 2025 · PMID 40381917 · doi:10.1016/j.jcmgh.2025.101534
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Also filed as BioProject PRJNA1149045 and SRA study SRP526917. Searching any of these in the dataset finder brings you back here.

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