Mutant-p53 stimulates Cxcl1 Expression from Distal Enhancers to Suppress Immune Response to Pancreatic Cancer [RNA-seq]
RNA-seq (gene expression) · mouse · 13 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 13 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Mutant p53 Exploits Enhancers to Elevate Immunosuppressive Chemokine Expression and Impair Immune Checkpoint Inhibitors in Pancreatic CancerbioRxiv : the preprint server for biology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275105_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1149454 and SRA study SRP527191. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 13 samples.
How we read this: 6 replicated groups read from 13 sample titles; they account for 13 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8465669 RNAseq_KPC_BR1 RNAseq_KPC_B
- GSM8465670 RNAseq_KPC_BR2 RNAseq_KPC_B
- GSM8465671 RNAseq_p53koKPC_isogenic_BR1 RNAseq_p53koKPC_isogeni…
- GSM8465672 RNAseq_p53koKPC_isogenic_BR2 RNAseq_p53koKPC_isogeni…
- GSM8465673 RNAseq_p53koKPC_isogenic_clone7_BR1 RNAseq_p53koKPC_isogeni…
- GSM8465674 RNAseq_p53koKPC_isogenic_clone7_BR2 RNAseq_p53koKPC_isogeni…
- GSM8465675 RNAseq_p53koKPC_syngenic_BR1 RNAseq_p53koKPC_syngeni…
- GSM8465676 RNAseq_p53koKPC_syngenic_BR2 RNAseq_p53koKPC_syngeni…
- GSM8465677 RNAseq_p53koKPC_isogenic_AddBack_BR1 RNAseq_p53koKPC_isogeni…
- GSM8465678 RNAseq_p53koKPC_isogenic_AddBack_BR2 RNAseq_p53koKPC_isogeni…
- GSM8465679 RNAseq_p53koKPC_isogenic_AddBack_BR3 RNAseq_p53koKPC_isogeni…
- GSM8465680 RNAseq_p53koKPC_isogenic_EmptyVector_BR1 RNAseq_p53koKPC_isogeni…
- GSM8465681 RNAseq_p53koKPC_isogenic_EmptyVector_BR2 RNAseq_p53koKPC_isogeni…
- GSE266918 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [heart] 63 samples shares pancreatic, rna-seq
- GSE266923 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [liver] 61 samples shares pancreatic, rna-seq
- GSE266920 RNA-seq expression analysis of liver, adipose, skeletal muscle, heart, and pancreatic islets from DO founder strain mice fed high-fat, high-sugar diet. [Adipose] 61 samples shares pancreatic, rna-seq
- GSE248585 A conserved epithelial wound-like transcriptional program driven by FOSL1 underlies malignant progression of pancreatic ductal adenocarcinoma (ssRNA-Seq) 46 samples shares pancreatic, rna-seq
- GSE263080 RNA-sea of Smad4 wild-type or Smad4 knockout KPC PDAC organoids from monocultures or co-cultures with pancreatic stellate cells and RNA-seq of flow-sorted PSCs from the same co-cultures. 44 samples shares pancreatic, rna-seq
- GSE278577 β2 ADRENERGIC SIGNALING STIMULATES EARLY IL-1β SECRETION IN MACROPHAGES BY INDUCING MAPK-DEPENDENT Il1b TRANSCRIPTION [RNA-Seq] 30 samples shares stimulates, rna-seq
- GSE291118 Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer [RNA-seq] 20 samples shares pancreatic, rna-seq
- GSE262879 Single-cell RNA-sequencing of murine pancreatic tumors derived from the orthotopic transplantation of Smad4 wild-type (WT) or Smad4 knockout (KO) pancreatic ductal adenocarcinoma (PDAC) KPC organoids in nu/nu mice. 18 samples shares pancreatic, rna-seq
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.