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Leydig Cells in Spermatogenesis-Deficient Testes Experience Stress, but Proliferate to Enhance Testosterone Synthesis I

GSE275209 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/12/27 Platform GPL23969Platform GPL24247
Summary
We investigated somatic cell dynamics in testicular tissue lacking spermatogenesis using model mice with testis-specific deletion of the histone H3 variant gene H3t. Leydig cells in testes lacking spermatogenesis led to increased testosterone synthesis that occurred alongside a high inflammatory response and oxidative stress.
Published in
Defects in the H3t Gene Cause an Increase in Leydig Cells With Impaired Spermatogenesis in Mice
Wu Q, Ito M, Fujii T et al. · Genes to cells : devoted to molecular & cellular mechanisms 2025 · PMID 39624989 · doi:10.1111/gtc.13182
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Also filed as BioProject PRJNA1149808 and SRA study SRP527375. Searching any of these in the dataset finder brings you back here.

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