Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon responses via MYC/CDK2/DNMT1 pathway
RNA-seq (gene expression) · mouse · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275283_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1150178 and SRA study SRP527590. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8474190 MCA205_cell_WT1 MCA205_cell_WT
- GSM8474191 MCA205_cell_WT2 MCA205_cell_WT
- GSM8474193 MCA205_cell_WT3 MCA205_cell_WT
- GSM8474194 MCA205_cell_sgNAT10_1 MCA205_cell_sgNAT10
- GSM8474195 MCA205_cell_sgNAT10_2 MCA205_cell_sgNAT10
- GSM8474196 MCA205_cell_sgNAT10_3 MCA205_cell_sgNAT10
- GSM8474197 TC1_cell_WT1 TC1_cell_WT
- GSM8474198 TC1_cell_WT2 TC1_cell_WT
- GSM8474199 TC1_cell_WT3 TC1_cell_WT
- GSM8474201 TC1_cell_sgNAT10_1 TC1_cell_sgNAT10
- GSM8474202 TC1_cell_sgNAT10_2 TC1_cell_sgNAT10
- GSM8474203 TC1_cell_sgNAT10_3 TC1_cell_sgNAT10
- GSM8474204 TC1_Tissue_WT1 TC1_Tissue_WT
- GSM8474205 TC1_Tissue_WT2 TC1_Tissue_WT
- GSM8474206 TC1_Tissue_WT3 TC1_Tissue_WT
- GSM8474207 TC1_Tissue_sgNAT10_1 TC1_Tissue_sgNAT10
- GSM8474208 TC1_Tissue_sgNAT10_2 TC1_Tissue_sgNAT10
- GSM8474209 TC1_Tissue_sgNAT10_3 TC1_Tissue_sgNAT10
- GSE285518 Inhibition of tumor-intrinsic NAT10 enhances antitumor immunity by triggering type I interferon responses via MYC/CDK2/DNMT1 pathway. 18 samples shares nat10, dnmt1, cdk2, myc, tumor-intrinsic, inhibition, triggering, interferon
- GSE313654 Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer [RNAseq_MycRux] 58 samples shares myc, interferon
- GSE309213 HDAC inhibition unlocks tumor plasticity and enhances immunotherapy response in Myc- Driven Small Cell Lung Cancer [ATAC-Seq] 12 samples shares myc, inhibition
- GSE263892 Single-cell analysis reveals Mycobacterium tuberculosis ESX-1-mediated accumulation of permissive macrophages in infected mouse lungs 6078 samples shares myc
- GSE263891 Single-cell analysis reveals Mycobacterium tuberculosis ESX-1–mediated accumulation of permissive macrophages in infected mouse lungs 6072 samples shares myc
- GSE288795 The geroprotectors trametinib and rapamycin combine additively to extend mouse healthspan and lifespan 111 samples shares myc
- GSE180529 A Dominant mutation in Dnmt1 leads epigenetic changes (Bulk RNAseq) 92 samples shares dnmt1
- GSE268757 Reproducible lung protective effects of a TGFβR1/ALK5 inhibitor in the bleomycin-induced and spirometry-confirmed mouse model of IPF 75 samples shares myc
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.