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Cellular Survivorship Bias as a Mechanistic Driver of Muscle Stem Cell Aging

GSE275358 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2026/02/26 Platform GPL24247
Summary
Aging is characterized by a significant impairment in the ability of muscle stem cells (MuSCs) to efficiently contribute to muscle regeneration. Here we uncover a novel cause of this aging-associated stem cell dysfunction - a cell-specific survivorship bias that prioritizes stem cell persistence at the expense of functionality. We show here that, with age, muscle stem cells upregulate a tumor suppressor, NDRG1, which, by blunting the mTOR pathway, increases their long-term survival potential but comes at the cost of their ability to promptly activate and contribute to muscle regeneration. These findings suggest that delayed muscle regeneration with age may be the result of a tradeoff that favors long term stem cell survival over immediate regenerative capacity.
Published in
Cellular survivorship bias as a mechanistic driver of muscle stem cell aging
Kang J, Benjamin DI, Guo Q et al. · Science (New York, N.Y.) 2026 · PMID 41610257 · doi:10.1126/science.ads9175
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Also filed as BioProject PRJNA1150536 and SRA study SRP527782. Searching any of these in the dataset finder brings you back here.

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