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Decreased estrogen level in ovariectomized mice causes an increase in oxidative stress in osteal macrophages leading to development of cellular senescence

GSE275459 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/11/26 Platform GPL24247
Summary
Osteal macrophages were isolated from ovariectomized and control mice 4 weeks after surgery. Oeritoneal macrophages collected from ovariectomized mice exhibited gene signature of NADPH oxidase activation which is known as key modulator in aging and cell senescence.
Published in
Dynamic transcriptome analysis of osteal macrophages identifies a distinct subset with senescence features in experimental osteoporosis
Nishida Y, Terkawi MA, Matsumae G et al. · JCI insight 2024 · PMID 39480497 · doi:10.1172/jci.insight.182418
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Also filed as BioProject PRJNA1150972 and SRA study SRP528064. Searching any of these in the dataset finder brings you back here.

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