Dual Targeting of STING and PI3Kγ Eliminates Regulatory B Cells to Overcome STING Resistance for Pancreatic Cancer Immunotherapy [RNA-seq]
RNA-seq (gene expression) · mouse · 17 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 17 samples: 17 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE275780_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1152981 and SRA study SRP528940. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 11 samples read as cases, 6 as controls.
How we read this: Read from 17 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8484461 B Cells, Control
- GSM8484462 B Cells, Control, replicate
- GSM8484463 B Cells, Control, replicate2
- GSM8484464 B Cells, MSA2+IPI-549 Treated
- GSM8484465 B Cells, MSA2+IPI-549 Treated, replicate
- GSM8484466 B Cells, MSA2+IPI-549 Treated, replicate2
- GSM8484467 B Cells, MSA2 Treated
- GSM8484468 B Cells, MSA2 Treated, replicate
- GSM8484469 B Cells, MSA2 Treated, replicate2
- GSM8484470 BMDC Cells, Control
- GSM8484471 BMDC Cells, Control, replicate
- GSM8484472 BMDC Cells, Control, replicate2
- GSM8484473 BMDC Cells, MSA2+IPI-549 Treated
- GSM8484474 BMDC Cells, MSA2+IPI-549 Treated, replicate
- GSM8484475 BMDC Cells, MSA2 Treated
- GSM8484476 BMDC Cells, MSA2 Treated, replicate
- GSM8484477 BMDC Cells, MSA2 Treated, replicate2
- GSE291447 Targeting CD11b+ regulatory B cells via RAS/RAF/PI3K pathway inhibition augments response to immune checkpoint blockade or CD40 agonism in metastatic melanoma 60 samples shares pi3k, regulatory, targeting
- GSE284365 IRE1α Downregulation Enhances STING-Mediated Chemoresistance and Guides Precision Therapies in Pancreatic Cancer 12 samples shares sting, resistance, pancreatic
- GSE290680 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 36 samples shares sting, pi3k
- GSE281467 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TIICs RNA-seq] 30 samples shares immunotherapy, resistance, targeting
- GSE281466 Coactivation of innate immune suppressive cells induces acquired resistance against cancer immunotherapy targeting the innate immune system [TME RNA-seq] 18 samples shares immunotherapy, resistance, targeting
- GSE320350 Nuclear class 3 PI3K co-activates fasting-specific chromatin remodeling 12 samples shares sting, pi3k
- GSE290828 Harnessing STING Signaling and Natural Killer Cells to overcome PARP Inhibitor Resistance in Homologous Recombination Repair altered Breast Cancer [RNA-seq] 20 samples shares sting, resistance
- GSE306986 Synergistic Stromal Remodeling and Dual Chemo-Immunotherapy in Pancreatic Cancer: A Two-Stage Losartan-Primed followed Nanocarrier Strategy for Tumor Microenvironment Reprogramming 24 samples shares immunotherapy, pancreatic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.