Direct mitochondrial import of lactate supports resilient carbohydrate oxidation
RNA-seq (gene expression) · mouse · 25 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 25 samples: 25 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Direct mitochondrial import of lactate supports resilient carbohydrate oxidationbioRxiv : the preprint server for biology · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276036_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1154550 and SRA study SRP529576. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 25 sample titles: 25 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8489888 24173X1 WT NO PUMP 1
- GSM8489889 24173X2 WT NO PUMP 2
- GSM8489890 24173X3 WT NO PUMP 3
- GSM8489891 24173X4 WT NO PUMP 4
- GSM8489892 24173X5 MCT1KO NO PUMP 1
- GSM8489893 24173X6 MCT1KO NO PUMP 2
- GSM8489894 24173X7 MCT1KO NO PUMP 3
- GSM8489895 24173X8 WT SALINE 1
- GSM8489896 24173X9 WT SALINE 2
- GSM8489897 24173X10 WT SALINE 3
- GSM8489898 24173X11 WT SALINE 4
- GSM8489899 24173X12 WT SALINE 5
- GSM8489900 24173X13 WT SALINE 6
- GSM8489901 24173X14 MCT1KO SALINE 1
- GSM8489902 24173X15 MCT1KO SALINE 2
- GSM8489903 24173X16 MCT1KO SALINE 3
- GSM8489904 24173X17 MCT1KO SALINE 4
- GSM8489905 24173X18 WT ANG/PE 1
- GSM8489906 24173X19 WT ANG/PE 2
- GSM8489907 24173X20 WT ANG/PE 3
- GSM8489908 24173X21 MCT1KO ANG/PE 1
- GSM8489909 24173X22 MCT1KO ANG/PE 2
- GSM8489910 24173X23 MCT1KO ANG/PE 3
- GSM8489911 24173X24 MCT1KO ANG/PE 4
- GSM8489912 24173X25 MCT1KO ANG/PE 5
- GSE186649 A mitochondrial long-chain fatty acid oxidation defect in a mouse leads to dysregulation of plasma long-chain acylcarnitines, dysregulation of plasma amino acids, and an increased reliance on glucocorticoid signaling to maintain euglycemia during fasting 50 samples shares mitochondrial, oxidation
- GSE186648 Skeletal muscle mRNA expression in 25 mice with or without genetic defects of mitochondrial fatty acid oxidation (Acadl and Acadvl knockout) using RNA sequencing. 25 samples shares mitochondrial, oxidation
- GSE266487 Mitophagy Mitigates Mitochondrial Fatty Acid β-oxidation Deficient Cardiomyopathy 16 samples shares mitochondrial, oxidation
- GSE341991 The role of glutaminolysis and mitochondrial pyruvate import on plasma cell differentiation 14 samples shares mitochondrial, import
- GSE285346 Mitochondrial metabolism and signaling direct dendritic cell function in antitumor immunity 39 samples shares mitochondrial, direct
- GSE239814 Mitochondrial signals mediate paternal effects on offspring metabolism (Smart-Seq) 221 samples shares mitochondrial
- GSE280991 Partial restoration of the mitochondrial dysfunction by AAV-Ant1 (Slc25a4) transduction protects against dilated cardiomyopathy in Slc25a4-/- plus mtDNA mutant mice 115 samples shares mitochondrial
- GSE296763 Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 99 samples shares mitochondrial
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.