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EED inhibitor impedes dendritic cell inflammatory functions

GSE276064 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/04/09 Platform GPL13112
Summary
Dendritic cells (DCs), the main antigen-presenting cells, are at the forefront of the immunity in response to autoimmune diseases. Epigenetic histone H3 lysine K27 trimethylation (H3K27me3) modification by embryonic ectoderm development (EED) is tightly associated with restrained transcriptional programs and has important functions in diverse biological processes and diseases, but its role in DC functionality remains elusive. In this study, we show that EED inhibitors block the activation especially migration of DCs, thus emphasizing EED as a pivotal regulator in DC homeostasis, which may be of great value for autoimmune disorders.
Published in
Inhibition of EED-mediated histone methylation alleviates neuroinflammation by suppressing WNT-mediated dendritic cell migration
Hong W, Ma H, Li Z et al. · Journal of neuroinflammation 2025 · PMID 40169990 · doi:10.1186/s12974-025-03429-z
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Also filed as BioProject PRJNA1154627 and SRA study SRP529720. Searching any of these in the dataset finder brings you back here.

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