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Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury

GSE276111 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/06/04 Platform GPL21103
Summary
Low-density lipoprotein receptor-related protein 6 (LRP6) is a receptor for Wnt ligands. Tissue fibrosis is a progressive pathological process with excessive extracellular matrix proteins (ECM) deposition. Myofibroblasts, identified by alpha-smooth muscle actin (αSMA) expression, play an important role in tissue fibrosis by producing ECM production and interacting with immune cells. Here we found that Dickkopf1 (DKK1) induced gene expressions is associated with inflammation and tissue repair in lung fibroblasts. We demonstrated that genetic deletion of LRP6 in αSMA-expressing cells using Acta2-cre Lrp6fl/fl (Lrp6AKO) mice abrogated bleomycin (BLM)-induced lung inflammation and fibrosis phenotype, suggesting a potential role for DKK1-LRP6 axis in modulating fibrotic processes. Our results highlight LRP6’s crucial role in fibroblasts in regulating inflammation and fibrosis upon BLM-induced lung injury.
Published in
Ablation of LRP6 in alpha-smooth muscle actin-expressing cells abrogates lung inflammation and fibrosis upon bleomycin-induced lung injury
Sung EA, Dozmorov MG, Song S et al. · FEBS letters 2025 · PMID 39873304 · doi:10.1002/1873-3468.15106
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Also filed as BioProject PRJNA1154700 and SRA study SRP529744. Searching any of these in the dataset finder brings you back here.

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