Epigenetic regulation of global proteostasis dynamics by RBBP5 ensures mammalian organismal health
RNA-seq (gene expression) · mouse · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 14 samples: 4 × RRBP5 LKO - Vehicle control vs 4 × RRBP5 LKO - Tunicamycin vs 3 × WT - Vehicle control vs 3 × WT - TunicamycinGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The SET1/COMPASS subunit RBBP5 orchestrates epigenetic control of global proteostasis and the 12h oscillator to safeguard metabolic and cellular homeostasisbioRxiv : the preprint server for biology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276159_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1155207 and SRA study SRP529936. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 4 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8492217 WT - Vehicle control - R1 WT - Vehicle control
- GSM8492218 WT - Vehicle control - R2 WT - Vehicle control
- GSM8492219 WT - Vehicle control - R3 WT - Vehicle control
- GSM8492220 WT - Tunicamycin - R1 WT - Tunicamycin
- GSM8492221 WT - Tunicamycin - R2 WT - Tunicamycin
- GSM8492222 WT - Tunicamycin - R3 WT - Tunicamycin
- GSM8492223 RRBP5 LKO - Vehicle control - R1 RRBP5 LKO - Vehicle con…
- GSM8492224 RRBP5 LKO - Vehicle control - R2 RRBP5 LKO - Vehicle con…
- GSM8492225 RRBP5 LKO - Vehicle control - R3 RRBP5 LKO - Vehicle con…
- GSM8492226 RRBP5 LKO - Vehicle control - R4 RRBP5 LKO - Vehicle con…
- GSM8492227 RRBP5 LKO - Tunicamycin - R1 RRBP5 LKO - Tunicamycin
- GSM8492228 RRBP5 LKO - Tunicamycin - R2 RRBP5 LKO - Tunicamycin
- GSM8492229 RRBP5 LKO - Tunicamycin - R3 RRBP5 LKO - Tunicamycin
- GSM8492230 RRBP5 LKO - Tunicamycin - R4 RRBP5 LKO - Tunicamycin
- GSE276155 RBBP5 is an epigenetic regulator of mammalian hepatic 12h oscillator [RNA-seq] 96 samples shares rbbp5, epigenetic, mammalian
- GSE325227 CD69 regulates the tissue dynamics of epigenetically imprinted memory CD4+ T cells [RNA-seq_ATAC-seq] 22 samples shares epigenetic, dynamics
- GSE241770 ACSS2 mediates an epigenetic pathway to regulate maternal Beta-cell adaptation and progression of gestational diabetes (scRNA-Seq) 7899 samples shares epigenetic
- GSE222745 Enhanced activities of OCT4 and SOX2 facilitates epigenetic reprogramming by modulating cell cycle [scRNA-Seq] 422 samples shares epigenetic
- GSE280168 The spatial zonation of the placental vasculature is specified by epigenetic mechanisms 383 samples shares epigenetic
- GSE243942 Spatio-temporal X-linked gene reactivation in the mouse germline reveals site-specific retention of epigenetic silencing [RNA-seq] 125 samples shares epigenetic
- GSE288355 A torpor-like state in mice slows blood epigenetic aging and prolongs healthspan 95 samples shares epigenetic
- GSE309564 IFNg shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms [RNA-Seq] 72 samples shares epigenetic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.