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HMGA2 overexpression drives a leiomyoma-like phenotype by modulating the epigenomic environment in primary myometrial cells [RNA-Seq]

GSE276286 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/10/01 Platform GPL18573
Summary
High-mobility group AT-hook 2 is a non-histone chromatin binding nuclear protein that belongs to the high-mobility group A family, which are known as "architectural transcription factors". Overexpression of HMGA2, resulting primarily due to chromosomal rearrangements of 12q15 loci, is considered a driver event in approximately 10% of uterine leiomyoma cases. To better understand how HMGA2 overexpression contributes to the formation of uterine leiomyoma, we generated primary myometrial cells engineered to overexpress HMGA2 (n=3) and determined the effect of HMGA2-overexpression on genome-wide mRNA levels, H3K27ac deposition, and chromatin accessibility.
Published in
Engineered uterine primary myometrial cells with high-mobility group AT-hook 2 overexpression display a leiomyoma-like transcriptional and epigenomic phenotype
Saini P, Holmes AG, Wei JJ et al. · F&S science 2024 · PMID 39074663 · doi:10.1016/j.xfss.2024.07.008
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Also filed as BioProject PRJNA1156548 and SRA study SRP530394. Searching any of these in the dataset finder brings you back here.

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