GEO series
Effect of p53 on the expression of combo induced dsRNAs in 2153L GEM tumors
GSE276354
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/10/16
GPL13112
Summary
We analyzed the expression of dsRNAs in control and p53 restored 2153L GEM tumors upon different treatments. Our ChIP-seq and RNA-seq experiments showed that the restored p53 bound to the regulatory regions of dsRNA-containing genes that account for 91% of the total dsRNA abundance in combination therapy–treated 2153L tumors, and suppressed their expression upon combination therapy. The abundance of dsRNA (TPM) was calculated from the dsRIP experiment.
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Paper (PMID 39419025) ↗
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