Data Mining of IFNgamma-induced macrophage and Atherosclerotic Plaque Transcriptomes predicts a macrophage-specific role of STAT1 in human atherosclerosis [BMDM]
Single-cell RNA-seq · mouse · 18 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Mus musculus (mouse)
- Samples
- 18 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Integrative multi-omics analysis of IFNγ-induced macrophages and atherosclerotic plaques reveals macrophage-dependent STAT1-driven transcription in atherosclerosisFrontiers in immunology · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276416_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1157326 and SRA study SRP530680. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 18 samples.
How we read this: 6 replicated groups read from 18 sample titles; they account for 18 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8498283 BMDM, UN, replicate 1 BMDM, UN,
- GSM8498284 BMDM, IFNy 0,5h, replicate 1 BMDM, IFNy 0,5h,
- GSM8498285 BMDM, IFNy 2h, replicate 1 BMDM, IFNy 2h,
- GSM8498286 BMDM, IFNy 4h, replicate 1 BMDM, IFNy 4h,
- GSM8498287 BMDM, IFNy 8h, replicate 1 BMDM, IFNy 8h,
- GSM8498288 BMDM, IFNy 24h, replicate 1 BMDM, IFNy 24h,
- GSM8498289 BMDM, UN, replicate 2 BMDM, UN,
- GSM8498290 BMDM, IFNy 0,5h, replicate 2 BMDM, IFNy 0,5h,
- GSM8498291 BMDM, IFNy 2h, replicate 2 BMDM, IFNy 2h,
- GSM8498292 BMDM, IFNy 4h, replicate 2 BMDM, IFNy 4h,
- GSM8498293 BMDM, IFNy 8h, replicate 2 BMDM, IFNy 8h,
- GSM8498294 BMDM, IFNy 24h, replicate 2 BMDM, IFNy 24h,
- GSM8498295 BMDM, UN, replicate 3 BMDM, UN,
- GSM8498296 BMDM, IFNy 0,5h, replicate 3 BMDM, IFNy 0,5h,
- GSM8498297 BMDM, IFNy 2h, replicate 3 BMDM, IFNy 2h,
- GSM8498298 BMDM, IFNy 4h, replicate 3 BMDM, IFNy 4h,
- GSM8498299 BMDM, IFNy 8h, replicate 3 BMDM, IFNy 8h,
- GSM8498300 BMDM, IFNy 24h, replicate 3 BMDM, IFNy 24h,
- GSE276418 Data Mining of IFNgamma-induced macrophage and Atherosclerotic Plaque Transcriptomes predicts a macrophage-specific role of STAT1 in human atherosclerosis 36 samples shares stat1, macrophage-specific, ifngamma-induced, atherosclerotic, atherosclerosis, transcriptomes, macrophage
- GSE276417 Data Mining of IFNgamma-induced macrophage and Atherosclerotic Plaque Transcriptomes predicts a macrophage-specific role of STAT1 in human atherosclerosis [VSMC] 18 samples shares stat1, macrophage-specific, ifngamma-induced, atherosclerotic, atherosclerosis, transcriptomes, macrophage
- GSE217269 RNA-seq analysis of Wild Type (WT) and Mettl3-/- (KO) BMDMs (bone-marrow-derived macrophages) Transcriptomes 6 samples shares bmdm, transcriptomes, macrophage
- GSE249265 Transcriptomics of BMDM treated with PTEN in the presence or absence of STAT1 inhibitors 16 samples shares stat1, bmdm
- GSE309564 IFNg shapes macrophage inflammatory responses by STAT1 isoform-specific epigenetic and transcriptional mechanisms [RNA-Seq] 72 samples shares stat1, macrophage
- GSE252014 Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen 57 samples shares stat1, macrophage
- GSE252009 Early and Delayed STAT1-Dependent Responses Drive Local Trained Immunity of Macrophages in the Spleen [bulk_RNA_seq_MS4A3] 53 samples shares stat1, macrophage
- GSE289356 Effects of type I IFN signaling on gene expression of Mycobacterium tuberculosis-infected bone marrow-derived macrophages (BMDMs) 34 samples shares bmdm, macrophage
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.