GEO series
The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations
GSE276453
Mus musculus (mouse)
RNA-seq (gene expression)
45 samples
Submitted 2024/10/01
Platform GPL21103
At a glance
RNA-seq (gene expression) · mouse · 45 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 45 samples: 45 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptationsMolecular psychiatry · 2025
Summary (written by the submitters)
Here, we explore the function of a drug-associated repressive transcription factor (TF), ZFP189, whose expression in the nucleus accumbens (NAc) facilitates cocaine-induced molecular and behavioral adaptations. To uncover the molecular action of ZFP189, we created synthetic ZFP189 TFs of distinct transcriptional function, including ZFP189VPR, which activates the expression of target genes and exerts opposite transcriptional control to the endogenously repressive ZFP189.
Read the full summary ↓
By virally delivering synthetic ZFP189 TFs to the NAc of mice, we discover that the molecular control exerted by synthetic or endogenous ZFP189 solely alters behavioral response to cocaine but not morphine or palatable food. Transcriptional adaptation occurred in response to cocaine, but not morphine. We demonstrate that NAc ZFP189 function drives the cocaine self-administration behaviors, whereas NAc ZFP189VPR impedes this worsening of cocaine taking behaviors. Collectively, this research illuminates the mechanisms through which a drug-associated TF specifically coordinates the brain adaptations necessary for the increasing of cocaine self-administration behaviors.
Published in
Picone JA, Hassan A, Kim RK et al.
· Molecular psychiatry 2025
· PMID 39587295
· doi:10.1038/s41380-024-02852-7
This dataset
Download · which file do I need?
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
1 · Just have a look
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
2 · Re-analyse it
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276453_RAW.tar (it can run to tens of gigabytes).
3 · Start from the raw reads
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1157405 and SRA study SRP530688. Searching any of these in the dataset finder brings you back here.
Study design
45 samples, each with a distinct title — no replicated groups
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 45 sample titles: 45 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
Samples in this study
- GSM8498759 Mouse (NFD-C-1) with NAc transduced with HSV-ZFP189NFD, Cocaine group, Day 7
- GSM8498760 Mouse (NFD-C-2) with NAc transduced with HSV-ZFP189NFD, Cocaine group, Day 7
- GSM8498761 Mouse (NFD-C-3) with NAc transduced with HSV-ZFP189NFD, Cocaine group, Day 7
- GSM8498762 Mouse (NFD-C-4) with NAc transduced with HSV-ZFP189NFD, Cocaine group, Day 7
- GSM8498763 Mouse (NFD-C-5) with NAc transduced with HSV-ZFP189NFD, Cocaine group, Day 7
- GSM8498764 Mouse (NFD-M-1) with NAc transduced with HSV-ZFP189NFD, Morphine group, Day 7
- GSM8498765 Mouse (NFD-M-2) with NAc transduced with HSV-ZFP189NFD, Morphine group, Day 7
- GSM8498766 Mouse (NFD-M-3) with NAc transduced with HSV-ZFP189NFD, Morphine group, Day 7
- GSM8498767 Mouse (NFD-M-4) with NAc transduced with HSV-ZFP189NFD, Morphine group, Day 7
- GSM8498768 Mouse (NFD-M-5) with NAc transduced with HSV-ZFP189NFD, Morphine group, Day 7
- GSM8498769 Mouse (NFD-S-1) with NAc transduced with HSV-ZFP189NFD, Saline group, Day 7
- GSM8498770 Mouse (NFD-S-2) with NAc transduced with HSV-ZFP189NFD, Saline group, Day 7
- GSM8498771 Mouse (NFD-S-3) with NAc transduced with HSV-ZFP189NFD, Saline group, Day 7
- GSM8498772 Mouse (NFD-S-4) with NAc transduced with HSV-ZFP189NFD, Saline group, Day 7
- GSM8498773 Mouse (NFD-S-5) with NAc transduced with HSV-ZFP189NFD, Saline group, Day 7
- GSM8498774 Mouse (VPR-C-1) with NAc transduced with HSV-ZFP189VPR, Cocaine group, Day 7
- GSM8498775 Mouse (VPR-C-2) with NAc transduced with HSV-ZFP189VPR, Cocaine group, Day 7
- GSM8498776 Mouse (VPR-C-3) with NAc transduced with HSV-ZFP189VPR, Cocaine group, Day 7
- GSM8498777 Mouse (VPR-C-4) with NAc transduced with HSV-ZFP189VPR, Cocaine group, Day 7
- GSM8498778 Mouse (VPR-C-5) with NAc transduced with HSV-ZFP189VPR, Cocaine group, Day 7
- GSM8498779 Mouse (VPR-M-1) with NAc transduced with HSV-ZFP189VPR, Morphine group, Day 7
- GSM8498780 Mouse (VPR-M-2) with NAc transduced with HSV-ZFP189VPR, Morphine group, Day 7
- GSM8498781 Mouse (VPR-M-3) with NAc transduced with HSV-ZFP189VPR, Morphine group, Day 7
- GSM8498782 Mouse (VPR-M-4) with NAc transduced with HSV-ZFP189VPR, Morphine group, Day 7
- GSM8498783 Mouse (VPR-M-5) with NAc transduced with HSV-ZFP189VPR, Morphine group, Day 7
- GSM8498784 Mouse (VPR-S-1) with NAc transduced with HSV-ZFP189VPR, Saline group, Day 7
- GSM8498785 Mouse (VPR-S-2) with NAc transduced with HSV-ZFP189VPR, Saline group, Day 7
- GSM8498786 Mouse (VPR-S-3) with NAc transduced with HSV-ZFP189VPR, Saline group, Day 7
- GSM8498787 Mouse (VPR-S-4) with NAc transduced with HSV-ZFP189VPR, Saline group, Day 7
- GSM8498788 Mouse (VPR-S-5) with NAc transduced with HSV-ZFP189VPR, Saline group, Day 7
- GSM8498789 Mouse (WT-C-1) with NAc transduced with HSV-ZFP189WT, Cocaine group, Day 7
- GSM8498790 Mouse (WT-C-2) with NAc transduced with HSV-ZFP189WT, Cocaine group, Day 7
- GSM8498791 Mouse (WT-C-3) with NAc transduced with HSV-ZFP189WT, Cocaine group, Day 7
- GSM8498792 Mouse (WT-C-4) with NAc transduced with HSV-ZFP189WT, Cocaine group, Day 7
- GSM8498793 Mouse (WT-C-5) with NAc transduced with HSV-ZFP189WT, Cocaine group, Day 7
- GSM8498794 Mouse (WT-M-1) with NAc transduced with HSV-ZFP189WT, Morphine group, Day 7
- GSM8498795 Mouse (WT-M-2) with NAc transduced with HSV-ZFP189WT, Morphine group, Day 7
- GSM8498796 Mouse (WT-M-3) with NAc transduced with HSV-ZFP189WT, Morphine group, Day 7
- GSM8498797 Mouse (WT-M-4) with NAc transduced with HSV-ZFP189WT, Morphine group, Day 7
- GSM8498798 Mouse (WT-M-5) with NAc transduced with HSV-ZFP189WT, Morphine group, Day 7
+ 5 more — browse all 45 samples with per-sample file links →
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