← BioTransfer GEO Dataset Finder
GEO series

Identification of DNMT1-interacting chromatin and its dynamic properties [ChIP-Seq]

GSE276510 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 6 samples Submitted 2025/06/18 Platform GPL19057
Summary
Epigenetic mechanisms are dynamic processes that govern gene expression in health and disease. DNA methylation, catalyzed by DNA methyltransferases (DNMTs) such as DNMT1, represents a stable but reversible process in which DNA is chemically modified to facilitate or prevent the binding of transcriptional regulators. Despite being a vital component of transcriptional regulation throughout all stages of life in health and disease, the sequence specificity of DNMT-binding is so far poorly understood. Here, we aimed to identify potential binding sites of DNMT1 as well as the dynamics of this process in immortalized, murine cerebellar granule cells, with and without the presence of a recombinant ephrinA5 protein, a ligand known to play a crucial role in neurodevelopment.
Published in
DNMT1-mediated regulation of somatostatin-positive interneuron migration impacts cortical architecture and function
Reichard J, Wolff P, Xie S et al. · Nature communications 2025 · PMID 40707493 · doi:10.1038/s41467-025-62114-0
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE276510_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 6 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1157751 and SRA study SRP531000. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 6 more — browse all 6 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.