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Gene expression profile at single cell level of immune cells from the deep cervical lymph nodes (dCLNs), superficial cervical lymph nodes (sCLNs), and inguinal lymph nodes (iLNs) of wild-type and Alzheimer's disease transgenic animals (5xFAD)vdjb

GSE276795 Mus musculus Expression profiling by high throughput sequencing 7 samples Submitted 2026/07/31 Platform GPL24247
Summary
The dCLNs are lymph nodes specialized in draining cerebrospinal fluid (CSF). We used single cell RNA sequencing (scRNA-seq) to characterize the immune cell populations in the dCLNs compared to other draining lymph nodes. We compared the immune landscape of the dCLNs between healthy WT mice and 5xFAD mice to investigate the role of dCLNs immunity in AD progression. Additionaly, we sequenced the TCR and BCR transcripts to analyze the clonal distribution of T-cells and B-cells in each lymph node.
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Also filed as BioProject PRJNA1159105 and SRA study SRP531768. Searching any of these in the dataset finder brings you back here.

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