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Impact of LINE-1 overexpression on gene expression in human induced pluripotent stem cell-derived microglia

GSE276905 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/12/06 Platform GPL34295
Summary
The aberrant expression of the transposable element LINE-1 is posited to impact cellular function and contribute to disease. We report that LINE-1 overexpression in these microglial cells drives significant functional and transcriptomic changes, including altered expression of genes associated with antigen presentation.
Published in
Elevated expression of the retrotransposon LINE-1 drives Alzheimer's disease-associated microglial dysfunction
Roy N, Haq I, Ngo JC et al. · Acta neuropathologica 2024 · PMID 39604588 · doi:10.1007/s00401-024-02835-6
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Also filed as BioProject PRJNA1159387 and SRA study SRP531946. Searching any of these in the dataset finder brings you back here.

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