GEO series
RNA decay profile for eRF1 and UPF1 depletion in HCT116 cell lines
GSE276918
Homo sapiens
Expression profiling by high throughput sequencing
48 samples
2025/05/31
GPL30209
Summary
We had found that non-optimal codon induced frameshifting translation coupled with NMD may play a crucial role in maintaining delicate need of mRNA from yeast to human. Our data suggests that NCFT also exist in human. We constructed eRF1-KD and UPF1-KD cell line and resort α-amanitin to treat cells in different time point, then transcriptionally profiled them to get the landscape of mRNA stability.
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