LOXL2 protects temporomandibular joint from mitochondrial dysfunction, apoptosis and osteoarthritis like progression
RNA-seq (gene expression) · mouse · 20 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 20 samples: 12 × LOXL2, Knockout, vs 8 × LOXL2, Control,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- LOXL2 deletion triggers TMJ osteoarthritis, while overexpression protects it from NF-κB-induced chondrocyte apoptosisInternational journal of oral science · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE276978_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1159874 and SRA study SRP532163. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 12 samples read as cases, 8 as controls.
How we read this: 2 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8510618 LOXL2, Control, Replicate1 LOXL2, Control,
- GSM8510619 LOXL2, Control, Replicate2 LOXL2, Control,
- GSM8510620 LOXL2, Control, Replicate3 LOXL2, Control,
- GSM8510621 LOXL2, Control, Replicate4 LOXL2, Control,
- GSM8510622 LOXL2, Control, Replicate5 LOXL2, Control,
- GSM8510623 LOXL2, Control, Replicate6 LOXL2, Control,
- GSM8510624 LOXL2, Control, Replicate7 LOXL2, Control,
- GSM8510625 LOXL2, Control, Replicate8 LOXL2, Control,
- GSM8510626 LOXL2, Knockout, Replicate1 LOXL2, Knockout,
- GSM8510627 LOXL2, Knockout, Replicate2 LOXL2, Knockout,
- GSM8510628 LOXL2, Knockout, Replicate3 LOXL2, Knockout,
- GSM8510629 LOXL2, Knockout, Replicate4 LOXL2, Knockout,
- GSM8510630 LOXL2, Knockout, Replicate5 LOXL2, Knockout,
- GSM8510631 LOXL2, Knockout, Replicate6 LOXL2, Knockout,
- GSM8510632 LOXL2, Knockout, Replicate7 LOXL2, Knockout,
- GSM8510633 LOXL2, Knockout, Replicate8 LOXL2, Knockout,
- GSM8510634 LOXL2, Knockout, Replicate9 LOXL2, Knockout,
- GSM8510635 LOXL2, Knockout, Replicate10 LOXL2, Knockout,
- GSM8510636 LOXL2, Knockout, Replicate11 LOXL2, Knockout,
- GSM8510637 LOXL2, Knockout, Replicate12 LOXL2, Knockout,
- GSE280991 Partial restoration of the mitochondrial dysfunction by AAV-Ant1 (Slc25a4) transduction protects against dilated cardiomyopathy in Slc25a4-/- plus mtDNA mutant mice 115 samples shares mitochondrial, dysfunction, protects
- GSE280273 A multi-omics census reveals miRNA miR-let-7 as instigator of paternal mitochondrial dysfunction and in epigenetic heredity of intergenerational metabolic decline [F0_Liv_eWAT_RNAseq] 36 samples shares mitochondrial, dysfunction
- GSE293219 Adipocyte-specific Mlkl knockout mitigates obesity-induced metabolic dysfunction by enhancing mitochondrial functions. 36 samples shares mitochondrial, dysfunction
- GSE300519 Neurotoxicity, α-Synuclein Pathology, and Mitochondrial Dysfunction: A Comparative Study of Three Parkinson’s Disease Mouse Models 35 samples shares mitochondrial, dysfunction
- GSE291086 Neuronal ABCA7 deficiency aggravates mitochondrial dysfunction and neurodegeneration in Alzheimer’s disease 24 samples shares mitochondrial, dysfunction
- GSE261940 Soluble ST2 induces cardiac contractile dysfunction by repressing mitochondrial electron transport chain genes in cardiomyocytes during fulminant myocarditis 20 samples shares mitochondrial, dysfunction
- GSE276088 Single-cell transcriptomic and spatial subcellular landscape of the articular disk synovium in mouse temporomandibular joint osteoarthritis 18 samples shares temporomandibular, osteoarthritis
- GSE291363 Mitochondrial dysfunction charachterizes the multigenerational effects of maternal obesity on MASLD 18 samples shares mitochondrial, dysfunction
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.