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Effect of mitochondria-targeted derivative of curcumin (Mitocurcumin; MC ) on gene expression in human Triple Negative Breast Cancer cell line, MDA-MB-231.

GSE276992 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2025/09/10 Platform GPL24676
Summary
RNA sequencing was performed to elucidate the anti-cancer mechanism of action of mitocurcumin in MDA-MB-231 Triple Negative Breast Cancer cells. Transcriptomic analysis revealed that mitocurcumin-treatment led to significant down-regulation of genes regulating cell proliferation, differentiation, vasculature development and DNA-binding transcription activator activity while the significantly up-regulated genes associated with starvation, oxidative stress, response to unfolded proteins and topologically incorrect proteins and intrinsic apoptosis. Mechanistically, in vitro and transcriptomics confirmed mitocurcumin-mediated induction of mitochondrial oxidative stress, bioenergetic stress and proteotoxic stress culminating in apoptosis.
Published in
Targeting mitochondrial proteases CLPP and LONP1 via disruption of mitochondrial redox homeostasis induces proteotoxic stress and suppresses tumor progression
Nandha SR, Patwardhan RS, Sharma D et al. · Cell communication and signaling : CCS 2025 · PMID 40903791 · doi:10.1186/s12964-025-02127-w
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Also filed as BioProject PRJNA1160168 and SRA study SRP532265. Searching any of these in the dataset finder brings you back here.

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