GEO series
Transcriptional dysregulation in a Mecp2 methyl-binding domain point mutant model (Mecp2 G118E)
GSE277077
Mus musculus
Expression profiling by high throughput sequencing
10 samples
2024/12/16
GPL17021
Summary
We recently identified a mutation in the methyl-binding domain of MECP2 (MECP2 G118E) in a male patient with Rett syndrome. To ask whether this mutation conferred similar molecular dysregulation as observed in previous mouse models of Rett syndrome, we generated a knockin mouse model of this mutation and collected the cortex for RNA-sequencing.
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