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Retinoic acid and TGF-β orchestrate organ-specific programs of tissue-residency

GSE277120 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/09/16 Platform GPL24247
Summary
Tissue-resident memory T (TRM) cells are integral to tissue immunity, persisting in diverse anatomical sites where they adhere to a common transcriptional framework. How these cells integrate distinct local cues to adopt the common TRM cell fate remains poorly understood. Here, we show that while skin TRM cells strictly require TGF-β for tissue residency, those in other locations utilize the metabolite retinoic acid (RA) to drive an alternative differentiation pathway, directing a TGF-β-independent tissue residency program in the liver and synergizing with TGF-β to drive the TRM cells in the small intestine.
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Direct links to NCBI, no account and no request form: the whole study as GSE277120_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1160824 and SRA study SRP532527. Searching any of these in the dataset finder brings you back here.

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