CCR2 limits inflammatory functions of CD8 TRM cells that impair recognition memory during recovery from WNV encephalitis [RNA-seq]
RNA-seq (gene expression) · mouse · 16 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 16 samples: 4 × HPC, cre-, vs 4 × HPC, Cd8-cre+, vs 4 × CTX, cre-, vs 4 × CTX, Cd8-cre+,Groups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CCR2 restricts IFN-γ production by hippocampal CD8 TRM cells that impair learning and memory during recovery from WNV encephalitisJournal of neuroinflammation · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE277152_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1160879 and SRA study SRP532564. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 4 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8515136 HPC, cre-, rep1 HPC, cre-,
- GSM8515137 HPC, cre-, rep2 HPC, cre-,
- GSM8515138 HPC, cre-, rep3 HPC, cre-,
- GSM8515139 HPC, cre-, rep4 HPC, cre-,
- GSM8515140 HPC, Cd8-cre+, rep1 HPC, Cd8-cre+,
- GSM8515141 HPC, Cd8-cre+, rep2 HPC, Cd8-cre+,
- GSM8515142 HPC, Cd8-cre+, rep3 HPC, Cd8-cre+,
- GSM8515143 HPC, Cd8-cre+, rep4 HPC, Cd8-cre+,
- GSM8515144 CTX, cre-, rep1 CTX, cre-,
- GSM8515145 CTX, cre-, rep2 CTX, cre-,
- GSM8515146 CTX, cre-, rep3 CTX, cre-,
- GSM8515147 CTX, cre-, rep4 CTX, cre-,
- GSM8515148 CTX, Cd8-cre+, rep1 CTX, Cd8-cre+,
- GSM8515149 CTX, Cd8-cre+, rep2 CTX, Cd8-cre+,
- GSM8515150 CTX, Cd8-cre+, rep3 CTX, Cd8-cre+,
- GSM8515151 CTX, Cd8-cre+, rep4 CTX, Cd8-cre+,
- GSE302945 A Pathogenic CD8⁺ TRM–Chemokine Axis Orchestrates Liver Fibrosis and Provides Circulating Biomarkers during Chronic Clonorchis sinensis Infection 16 samples shares cd8, trm
- GSE223164 Osr2 functions as a biomechanical checkpoint to aggravate CD8+ T cell exhaustion in tumor 49 samples shares cd8, functions
- GSE223157 Osr2 functions as a mechanical checkpoint to augment CD8+ T cell exhaustion [YODA1_vs_DMSO_ATAC_CD8] 12 samples shares cd8, functions
- GSE296763 Mitochondrial respiration is necessary for CD8 T cell proliferation and cell fate 99 samples shares cd8
- GSE334845 Discovery of Tcf7 regulators with clonally-resolved CRISPR screens identifies Trim28 as a mediator of CD8 T cell differentiation in tumors [RNA-Seq] 86 samples shares cd8
- GSE235059 ICOSL, OX40L, and CD30L Control Persistence of Asthmatic CD4 Trm Cells 80 samples shares trm
- GSE302682 Sleeping Beauty mutagenesis identifies BACH2 and other regulators promoting CD8+ T cell persistence and effector function under tumor-associated chronic antigen stimulation - RNAseq 66 samples shares cd8
- GSE277303 Inducible CCR2+ nonclassical monocytes mediate the regression of cancer metastasis 42 samples shares ccr2
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.