← BioTransfer GEO Dataset Finder
GEO series

Regulation of the type I interferon response by chromatin organization (ATAC-seq of L929 fibroblasts +/- SEV)

GSE277288 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2026/01/13 Platform GPL24247
Summary
Antiviral type I interferons (IFN-I) including IFN-β and multiple subtypes of IFN-α are encoded within a single locus. Whereas most cell types produce primarily IFN-β, plasmacytoid dendritic cells (pDCs) respond to viruses by rapidly producing all IFN-I subtypes. We show that during pDC differentiation, the IFN-I locus translocates from the nuclear periphery and undergoes reorganization of topologically associated domains (TADs). Accordingly, IFN-I production by pDCs was strictly dependent on the TAD-organizing cohesin complex. Promoters of Ifna genes in pDCs were poised, which was imparted by the pDC-enriched transcription factor IRF8. Finally, we identified two distal regulatory regions that facilitated the expression of adjacent IFN-I genes. Thus, the IFN-I response is controlled by multilevel chromatin organization of the IFN-I locus, including its unique poised state in pDCs.
Published in
Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells
Adams NM, Galitsyna A, Tiniakou I et al. · Science immunology 2026 · PMID 41650249 · doi:10.1126/sciimmunol.adx4622
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE277288_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1161656 and SRA study SRP532945. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 4 more — browse all 4 samples with per-sample file links →

Similar datasets

Search all mouse ChIP / ATAC / CUT&Tag datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.